发明名称 SUBSTITUTED ISOXAZOLE COMPOUNDS
摘要 Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein Q is R1 is alkyl or aryl, said aryl optionally substituted with one to five substituents independently selected from C1 to C6 alkyl, C1 to C4 haloalkyl, —OR4, and/or halogen; and R2, R3, R4, and n are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
申请公布号 US2011300165(A1) 申请公布日期 2011.12.08
申请号 US201013145730 申请日期 2010.01.22
申请人 WATTERSON SCOTT HUNTER;DYCKMAN ALARIC J.;PITTS WILLIAM J.;SPERGEL STEVEN H.;THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOI UNIVERSITY OF ILLINIOS 发明人 WATTERSON SCOTT HUNTER;DYCKMAN ALARIC J.;PITTS WILLIAM J.;SPERGEL STEVEN H.
分类号 A61K31/4245;A61P3/10;A61P11/06;A61P17/06;A61P19/02;A61P25/00;A61P29/00;A61P37/06;C07D413/14 主分类号 A61K31/4245
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