| 发明名称 |
CHIMERIC AND HUMANIZED ANTIBODIES TO ALPHA5BETA1 INTEGRIN THAT MODULATE ANGIOGENESIS |
| 摘要 |
The present invention provides chimeric and humanized antibodies that specifically recognize α5&bgr;1 integrin, and methods for using the antibodies for reducing or inhibiting angiogenesis in a tissue. Also provided are methods of determining therapeutically acceptable doses of the antibodies and pharmaceutical compositions including the same. |
| 申请公布号 |
US2011300133(A1) |
申请公布日期 |
2011.12.08 |
| 申请号 |
US201113009757 |
申请日期 |
2011.01.19 |
| 申请人 |
RAMAKRISHNAN VANITHA;POWERS DAVID;JOHNSON DALE E.;JEFFRY URSULA;BHASKAR VINAY;ABBOTT BIOTHERAPEUTICS CORP. |
发明人 |
RAMAKRISHNAN VANITHA;POWERS DAVID;JOHNSON DALE E.;JEFFRY URSULA;BHASKAR VINAY |
| 分类号 |
A61K39/395;A61P27/02;C07K16/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
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