Methods and compositions for improving recombinant protein production

摘要

Nucleic acid molecules modified to enhance recombinant protein expression, e.g., that of A&bgr; peptide binding antibodies, and/or to reduce or eliminate mis-spliced and/or intron read-through (IRT) by-products are disclosed. The invention also provides methods for producing A&bgr; peptide binding antibodies devoid of mis-spliced and/or intron read-through by-products by expression of such nucleic acid molecules under cell culture conditions suitable for recombinant A&bgr; peptide binding antibody expression.