A process for manufacturing Rosuvastatin Potassium and crystalline and amorphous forms thereof

摘要

A process of manufacturing of Rosuvastatin Potassium of formula (1) is disclosed. The process comprises the steps of (a) treating Rosuvastatin protected compound of formula (II) wherein R and R are same or different having C-C carbon atom or hydrogen or R and R can combine together to afford a cyclic structure comprising a junction atom as carbon or metal atom such as Si (silicon); with an inorganic base of the kind such as herein described having potassium as cation in a suitable solvent to form Rosuvastatin potassium; (b) isolating Rosuvastatin potassium.