发明名称 |
Treatment of radiation-induced fibrosis |
摘要 |
The present invention relates to treatment or prevention of radiation induced fibrosis using TNF-alpha antagonism. Preferably, TNF-alpha is antagonized by direct binding or by inhibition of synthesis. In a preferred embodiment, the invention comprises intraperitoneal administration of a chitosan-siRNA nanoparticle, wherein the siRNA is targeted to the mRNA encoding TNF-alpha. |
申请公布号 |
EP2391717(A1) |
申请公布日期 |
2011.12.07 |
申请号 |
EP20100702018 |
申请日期 |
2010.01.28 |
申请人 |
AARHUS UNIVERSITET;REGION, MIDTJYLLAND |
发明人 |
HOWARD, KENNETH ALAN;KJEMS, JOERGEN;BESENBACHER, FLEMMING;NAWROTH, ISABEL;ALSNER, JAN;OVERGAARD, JENS |
分类号 |
C12N15/113;A61K31/713;A61P19/04 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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