发明名称 |
Methods of inhibiting B lymphocytes using antibodies to Neutrokine-alpha |
摘要 |
The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders. |
申请公布号 |
US8071092(B1) |
申请公布日期 |
2011.12.06 |
申请号 |
US20000589288 |
申请日期 |
2000.06.08 |
申请人 |
YU GUO-LIANG;EBNER REINHARD;NI JIAN;HUMAN GENOME SCIENCES, INC. |
发明人 |
YU GUO-LIANG;EBNER REINHARD;NI JIAN |
分类号 |
A61K39/395;A61K38/00;C07H21/04;C07K14/475;C07K14/52;C07K14/715;C07K16/22;C07K16/24;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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