发明名称 |
NOVEL MALEIMIDE COMPOUND HAVING 1,2,3-TRIAZOLE GROUP, PREPARATION METHOD THEREOF AND F-18 LABELING METHOD OF BIOMOLECULE USING PROSTHETIC GROUP |
摘要 |
PURPOSE: A maleimide compound labeled with fluorine-18(^18F) and a method for labeling ^18F of biocompounds are provided to simplify production process and to reduce production time. CONSTITUTION: A maleimide compound with 1,2,3-triazole group is denoted by chemical formula 1. A method for preparing the maleimide compound comprises: a step of performing nucleophilic fluorination of sulfonate precursor of chemical formula 2 under the presence of an organic solvent to prepare fluoroalkyl azide compound of chemical formula 3; and a step of reacting the compound of chemical formula 3 with maleimide with terminal alkyne group of chemical formula 4 under the presence of an organic solvent and copper catalyst to prepare a compound of chemical formula 1. A method for labeling ^18F to a biocompound comprises: a step of stirring ^18F-labeled compound of chemical formula 1 with the biocompound with SH functional groups under the presence of PBS solution; and a step of collecting ^18F-labeled biocompound of chemical formula 6.
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申请公布号 |
KR20110131022(A) |
申请公布日期 |
2011.12.06 |
申请号 |
KR20100050628 |
申请日期 |
2010.05.28 |
申请人 |
INDUSTRY-UNIVERSITY COOPERATION FOUNDATION SOGANGUNIVERSITY |
发明人 |
CHI, DAE YOON;LEE, BYOUNG SE;LEE, BO RAM;CHU, SO YOUNG;LEE, SANG JU |
分类号 |
C07D403/04;C07D403/02;G01N33/58 |
主分类号 |
C07D403/04 |
代理机构 |
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