发明名称 Alkylquinoline and alkylquinazoline kinase modulators
摘要 The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: wherein R1, R2, R3, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.
申请公布号 US8071768(B2) 申请公布日期 2011.12.06
申请号 US20060422349 申请日期 2006.06.06
申请人 BAINDUR NAND;GAUL MICHAEL DAVID;KREUTTER KEVIN DOUGLAS;BAUMANN CHRISTIAN ANDREW;KIM ALEXANDER J.;XU GUOZHANG;TUMAN ROBERT W.;JOHNSON DANA L.;JANSSEN PHARMACEUTICA, N.V. 发明人 BAINDUR NAND;GAUL MICHAEL DAVID;KREUTTER KEVIN DOUGLAS;BAUMANN CHRISTIAN ANDREW;KIM ALEXANDER J.;XU GUOZHANG;TUMAN ROBERT W.;JOHNSON DANA L.
分类号 C07D401/00;C07D413/00 主分类号 C07D401/00
代理机构 代理人
主权项
地址