发明名称 |
End-modified poly(beta-amino esters) and uses thereof |
摘要 |
Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers. |
申请公布号 |
US8071082(B2) |
申请公布日期 |
2011.12.06 |
申请号 |
US20070780754 |
申请日期 |
2007.07.20 |
申请人 |
ZUGATES GREGORY T.;ZUMBUEHL ANDREAS;LANGER ROBERT S.;ANDERSON DANIEL G.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
ZUGATES GREGORY T.;ZUMBUEHL ANDREAS;LANGER ROBERT S.;ANDERSON DANIEL G. |
分类号 |
A61K31/765;A61K9/00;A61K48/00;C08F26/00;C12N15/11 |
主分类号 |
A61K31/765 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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