发明名称 |
Thioester-terminated water soluble polymers and method of modifying the N-terminus of a polypeptide therewith |
摘要 |
The invention provides reagents and methods for conjugating a polymer specifically to the α-amine of a polypeptide. The invention provides monofunctional, bifunctional, and multifunctional PEGs and related polymers having a terminal thioester moiety capable of specifically conjugating to the α-amine of a polypeptide having a cysteine or histidine residue at the N-terminus. The invention provides reactive thioester-terminated PEG polymers that have suitable reactivity with an N-terminal cysteine or histidine residue of a polypeptide to produce an amide bond between the PEG molecule and the polypeptide. |
申请公布号 |
US8071678(B2) |
申请公布日期 |
2011.12.06 |
申请号 |
US20100902072 |
申请日期 |
2010.10.11 |
申请人 |
ROBERTS MICHAEL J.;FANG ZHIHAO;NEKTAR THERAPEUTICS |
发明人 |
ROBERTS MICHAEL J.;FANG ZHIHAO |
分类号 |
C07K1/113;C08G63/50;A61K47/48;C07K14/555;C08G65/334 |
主分类号 |
C07K1/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|