| 发明名称 |
TGF-BETA SUPERFAMILY MUTANT MEMBERS, INCLUDING MORPHOGENIC PROTEINS |
| 摘要 |
The invention provides modified proteins and DNAs of the TGF-.beta. superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through manipulation of exchange of subdomains among two or more members of the superfamily such that certain desired attributes are mixed-and-matched and then exploited therapeutically.
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| 申请公布号 |
CA2345287(C) |
申请公布日期 |
2011.12.06 |
| 申请号 |
CA19992345287 |
申请日期 |
1999.10.07 |
| 申请人 |
STRYKER CORPORATION |
发明人 |
OPPERMANN, HERMANN;TAI, MEI-SHENG;MCCARTNEY, JOHN |
| 分类号 |
C12N15/62;G01N33/50;A61K38/00;A61P1/02;A61P1/16;A61P19/00;A61P43/00;C07K14/47;C07K14/495;C07K14/51;C07K19/00;C12N5/06;C12N15/09;C12N15/12;C12P21/02;G01N33/15;G01N33/53 |
主分类号 |
C12N15/62 |
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