发明名称 |
Protective skin care peptides |
摘要 |
The disclosed invention provides tetrapeptides with the amino acid sequence proline-glutamine-glutamate-X (P-Q-E-X), where X can be either lysine (K) or isoleucine (I). These tetrapeptides inhibit ultraviolet light (UV)-induced expression of the pro-inflammatory cytokine interleukin-6 (IL-6) by skin epithelial cells and fibroblasts. Furthermore, the tetrapeptides repress the upregulation of matrix metalloproteinase-1 (MMP-1) by skin fibroblasts induced by either direct exposure to UV rays or treatment with media conditioned by UV-treated keratinocytes. The small size and bio-activity of the tetrapeptides render them suitable for use in therapies directed to inflammatory skin disorders and as active ingredients in skin care products. |
申请公布号 |
US8071555(B2) |
申请公布日期 |
2011.12.06 |
申请号 |
US20080290236 |
申请日期 |
2008.10.28 |
申请人 |
ZHANG LIJUAN;HARRIS SCOTT M.;FALLA TIMOTHY J.;HELIX BIOMEDIX INC. |
发明人 |
ZHANG LIJUAN;HARRIS SCOTT M.;FALLA TIMOTHY J. |
分类号 |
A61K38/06;A61K9/00 |
主分类号 |
A61K38/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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