发明名称 |
OPTIMIZED EARLY-LATE PROMOTER COMBINED WITH REPEATED VACCINATION FAVORS CYTOTOXIC T CELL RESPONSE AGAINST ANTIGENS IN REPLICATION DEFICIENT RECOMBINANT VIRUS VACCINES |
摘要 |
The invention is drawn to compositions and methods for the induction of a strong CD8 T cell response to a specific antigen(s). The combination of an early/late hybrid promoter directing strongly enhanced early expression of a neoantigen with at least three immunization rounds resulted in a highly efficient neoantigen-specific CD8 T cell response. This combination reversed the immunodominance hierarchy and converted a moderately immunogenic and subdominant CD8 T cell epitope into the immunodominant epitope. |
申请公布号 |
KR20110129954(A) |
申请公布日期 |
2011.12.02 |
申请号 |
KR20117024016 |
申请日期 |
2010.03.11 |
申请人 |
BAVARIAN NORDIC A |
发明人 |
BRINKMANN KAY;BAUR KAREN;HAUSMANN JUERGEN |
分类号 |
C12N7/01;A61K39/12;C07K14/005;C12N7/04 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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