发明名称 |
SUBSTITUTED-6-METHYLNICOTINAMIDES AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS |
摘要 |
<p>In one aspect, the invention relates to substituted 6-methylnicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.</p> |
申请公布号 |
CA2799966(A1) |
申请公布日期 |
2011.12.01 |
申请号 |
CA20112799966 |
申请日期 |
2011.05.24 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
CONN, P. JEFFREY;LINDSLEY, CRAIG W.;STAUFFER, SHAUN R.;ZHOU, YA;MANKA, JASON;MCDONALD, GREGOR JAMES;BARTOLOME-NEBREDA, JOSE MANUEL |
分类号 |
A61K31/455;A61P25/00 |
主分类号 |
A61K31/455 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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