摘要 |
<p>Provided are phenylbutyryl curcumin derivatives, their preparation methods, pharmaceutical compositions containing said derivatives and uses thereof for preparing anti-tumor drugs. Said curcumin derivatives are specifically 4-[bis(2-chloroethyl)amino]phenylbutyryl curcumin and 4,4'-bis[bis(2-chloroethyl)amino]phenylbutyryl curcumin, and their pharmaceutically acceptable salts. The curcumin derivatives are effective on inhibiting various animal tumor cell transplantation models in vivo, and do not have serious toxicity in mouse.</p> |
申请人 |
FUJIAN MEDICAL UNIVERSITY;XU, JIANHUA;LIU, YANG;WU, LIXIAN;LIN, YANFANG;WU, ZHIJUAN;GUO, XIAODAN;WU, MIN |
发明人 |
XU, JIANHUA;LIU, YANG;WU, LIXIAN;LIN, YANFANG;WU, ZHIJUAN;GUO, XIAODAN;WU, MIN |