ION EXCHANGERS AND METHODS OF USE THEREOF

摘要

This invention provides a method of treating a disease by stimulating or accelerating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention further provides a method of treating a disease by diminishing or abrogating calcium flux via a mitochondrial Na+/Ca2+ NCLX exchanger. This invention also provides compounds and compositions comprising the same for diminishing or abrogating mitochondrial Na+/Ca2+-Li+ exchanger (NCLX) expression or activity, thereby inhibiting apoptosis, or for stimulating or increasing mitochondrial Na+/Ca2+ NCLX exchanger expression or activity, thereby stimulating or accelerating apoptosis. This invention further provides compounds and compositions comprising the same for modulating apoptosis and treating diseases, disorders and/or conditions related thereto.