摘要 |
<p>Disclosed is a synthesis method of a compound of formula 1, 5-[[2(R)-[1(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-4-fluorophenyl-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazole-3-one (i.e. aprepitant), which comprises cyclising a compound of formula 4 in a solvent, wherein R is C1-C5 alkyl. The intermediate for preparing aprepitant is also disclosed. The present method is especially suitable for industrial production of aprepitant.</p> |
申请人 |
CHENGDU DI'AO PHARMACEUTICAL GROUP CO. LTD;JI, JIANXIN;ZHANG, QIANG;DU, FENGTIAN;JIN, YI;ZHANG, TAO;GUO, NA;YAN, XIAOWEI;YANG, YONGRONG;LI, BOGANG |
发明人 |
JI, JIANXIN;ZHANG, QIANG;DU, FENGTIAN;JIN, YI;ZHANG, TAO;GUO, NA;YAN, XIAOWEI;YANG, YONGRONG;LI, BOGANG |