发明名称 |
P38 MAP KINASE INHIBITORS |
摘要 |
The invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, including all stereoisomers, tautomers and isotopic derivatives thereof, which are inhibitors of p38 mitogen-activated protein kinase enzymes (referred to herein as p38 MAP kinase inhibitors), particularly the alpha and gamma kinase sub-types thereof, and their use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, such as COPD. |
申请公布号 |
US2011294812(A1) |
申请公布日期 |
2011.12.01 |
申请号 |
US200913133998 |
申请日期 |
2009.12.11 |
申请人 |
ITO KAZUHIRO;STRONG PETER;RAPEPORT WILLIAM GARTH;MURRAY PETER JOHN;KING-UNDERWOOD JOHN;WILLIAMS JONATHAN GARETH;ONIONS STUART THOMAS;HIRST SIMON CHRISTOPHER;TADDEI DAVID MICHEL ADRIEN;CHARRON CATHERINE ELISABETH |
发明人 |
ITO KAZUHIRO;STRONG PETER;RAPEPORT WILLIAM GARTH;MURRAY PETER JOHN;KING-UNDERWOOD JOHN;WILLIAMS JONATHAN GARETH;ONIONS STUART THOMAS;HIRST SIMON CHRISTOPHER;TADDEI DAVID MICHEL ADRIEN;CHARRON CATHERINE ELISABETH |
分类号 |
A61K31/4439;A61K31/496;A61K31/5377;A61P1/04;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/02;A61P29/00;A61P35/00;A61P35/04;C07D401/12;C07D401/14;C07D405/14;C07D413/14 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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