发明名称 |
TREATMENT OF AMYLOIDOSES USING MYELIN BASIC PROTEIN AND FRAGMENTS THEREOF |
摘要 |
In its various embodiments, the invention provides myelin basic proteins and fragments of that interfere with the fibril lization of peptides implicated in the amyloidoses, especially the amyloid-beta peptide associated with Alzheimer's disease (“AD”) and cerebral amyloid angiopathy (“CAA”). Some embodiments provide methods of identifying additional interfering fragments. Others provide methods of identifying substances that modulate the interference. Further embodiments provide methods of preventing amyloidoses, especially AD and CAA by administering myelin basic proteins or fragments thereof. |
申请公布号 |
US2011294740(A1) |
申请公布日期 |
2011.12.01 |
申请号 |
US200913061433 |
申请日期 |
2009.08.28 |
申请人 |
VAN NOSTRAND WILLIAM E.;THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK |
发明人 |
VAN NOSTRAND WILLIAM E. |
分类号 |
A61K38/17;A61K48/00;A61P25/00;C07K7/06;C07K14/47;G01N33/566 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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