METHOD AND COMPOSITION FOR WHOLE GENOME AMPLIFICATION AND GENOTYPING

摘要

PROBLEM TO BE SOLVED: To provide a method and a composition for the whole genome amplification and genotyping.

SOLUTION: A method for detecting typable loci of a genome comprises the following steps of: (a) providing an amplified representative population of genome fragments comprising the typable loci where the population comprises a high complexity representation; (b) making the genome fragments contact with a plurality of different nucleic acid probes having sequences corresponding to the typable loci under conditions that probe-fragment hybrids are formed; and (c) directly detecting typable loci of the probe-fragment hybrids.

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