| 摘要 |
Claimed is an apparatus comprising an by using any of the methods of GB1012395.8 in-situ calibrated atomic force microscope, which is here applied to quantitatively measuring normal and lateral forces, elasticities and viscosities and of course spatial measures on biological/organic objects. In particular, elasticities, viscosities and mechanical resonance frequencies are quantitatively evaluated, in particular based on the "vertical" (normal and lateral tip forces, sample elasticities and heights, tip-sample-distance) in-situ calibration following the methods in GB1012395.8 of this particular atomic force microscopy e.g. for a typological classification of various biological/organic objects for instance for distinguishing healthy from sick cells or cell-organelles and for designing physical methods to specifically destroy e.g. sick cells or virulent particles in a living organism. Furthermore, receptor binding forces are quantified, in particular exploiting calibrated lateral tip forces. Finally, the method for standardizing the effective sample temperature on a small spatial scale via in-situ detecting by AFM the in particular 2-dimensional crystallization parameters of nanoparticles can be applied as a spin-off application for repairing materials like glass windows. |
