发明名称 |
METHOD FOR ACTIVATING PRETHROMBIN-1 |
摘要 |
Methods for converting prethrombin-1 to thrombin are disclosed. An aqueous solution of prethrombin-1 is applied to oscutarin-C immobilized on a solid support so as to provide from 500 mg to 4000 mg of prethrombin-1 per mL of the solid support and a contact time between the prethrombin-1 and the oscutarin-C of from 1.8 to 3.5 minutes. The resulting active thrombin may be captured on an ion exchange chromatography medium or an affinity chromatography medium. |
申请公布号 |
SI1966371(T1) |
申请公布日期 |
2011.11.30 |
申请号 |
SI20060031148T |
申请日期 |
2006.12.21 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
MALLET ROBERT W.;STENLAND CHRISTOPHER J.;BOONE JONATHON C.;FORSTROM JOHN W.;DE JONGH KAREN S. |
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