SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS

摘要

THIS INVENTION IS DIRECTED TO SPIRO-OXINDOLE COMPOUNDS OF FORMULA (I): WHEREIN K, J, Q, R1, R2A, R2B, R2C, R2D, R3A, R3B, R3C, AND R3D ARE AS DEFINED HEREIN, AS A STEREOISOMER, ENANTIOMER, TAUTOMER THEREOF OR MIXTURES THEREOF; OR A PHARMACEUTICALLY ACCEPTABLE SALT, SOLVATE OR PRODRUG THEREOF, WHICH ARE USEFUL FOR THE TREATMENT AND/OR PREVENTION OF SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS, SUCH AS PAIN. PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUNDS AND METHODS OF PREPARING AND USING THE COMPOUNDS ARE ALSO DISCLOSED.