发明名称 |
ANTI-CD 160 MONOCLONAL ANTIBODIES AND USES THEREOF |
摘要 |
<p>The present application concerns an antibody or fragment thereof; capable of binding to CD 160, said antibody comprising a) a light chain comprising three light chain complementary regions (CDRs) having the following amino acid sequences: (i) the light chain CDR1: QSISNH (SEQ ID NO: 1), (ii) the light chain CDR2: YAS, (iii) the light chain CDR3: QQSNSWPLT (SEQ ID NO: 2), and a light chain framework sequence from an inimunoglobulin light chain; and b) a heavy chain comprising three heavy chain complementary regions (CDRs) having the following amino acid sequences: (i) the heavy chain CDR1: GYTFTDYW (SEQ TD NO: 3), (ii) the heavy chain CDR2: IYPGDDDA (SEQ ID NO: 4); (iii) the heavy chain CDR3: ARRGIAAVVGGFDY (SEQ ID NO: 5); and a heavy chain framework sequence from an immunoglobulin heavy chain; a pharmaceutical comprising said antibody and the use of said antibody for preparation of a medieament for treating and/or preventing a pathology associated with endothelial cells proliferation engaged in an angiogenesis process.</p> |
申请公布号 |
EP2389393(A1) |
申请公布日期 |
2011.11.30 |
申请号 |
EP20100701011 |
申请日期 |
2010.01.21 |
申请人 |
MONOCLONAL ANTIBODIES THERAPEUTICS;INSERM - INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE |
发明人 |
DIDIERLAURENT, DENIS;CHOSE, OLIVIER;KADOUCHE, JEAN |
分类号 |
C07K16/28;A61K39/395;A61P9/10;A61P37/06;C07K16/46 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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