发明名称 Heterofused piperidines as orexin antagonists
摘要 The present invention relates to compounds of formula wherein R1, R2, R3, and R4 are as defined herein and hetaryl is a one or two ring-membered heteroaromatic ring system, connected to the carbon atoms of the piperidine group selected from the group consisting of or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. These compounds are orexin receptor antagonists and may be useful in the treatment of disorders in which orexin pathways are involved, like sleep disorders.
申请公布号 US8067598(B2) 申请公布日期 2011.11.29
申请号 US20080056324 申请日期 2008.03.27
申请人 GOBBI LUCA;KNUST HENNER;MALHERBE PARICHEHR;NETTEKOVEN MATTHIAS;PINARD EMMANUEL;ROCHE OLIVIER;ROGERS-EVANS MARK;HOFFMAN-LA ROCHE INC. 发明人 GOBBI LUCA;KNUST HENNER;MALHERBE PARICHEHR;NETTEKOVEN MATTHIAS;PINARD EMMANUEL;ROCHE OLIVIER;ROGERS-EVANS MARK
分类号 C07D471/04;A61K31/4365;A61K31/437;A61K31/4375;C07D513/04 主分类号 C07D471/04
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