发明名称 |
Methods and compositions for delivery of growth factor to fibrous connective tissue |
摘要 |
The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions. |
申请公布号 |
US8067021(B2) |
申请公布日期 |
2011.11.29 |
申请号 |
US20080204731 |
申请日期 |
2008.09.04 |
申请人 |
BUEHRER BENJAMIN MARCUS;HAMILTON PAUL;JUZUMIENE DALIA;NAIR SHRIKUMAR;CHEN YUCHEN;AFFINERGY, INC. |
发明人 |
BUEHRER BENJAMIN MARCUS;HAMILTON PAUL;JUZUMIENE DALIA;NAIR SHRIKUMAR;CHEN YUCHEN |
分类号 |
A61F13/00;A61K38/00;A61K38/10;A61K38/16;A61K38/18;C07K14/475 |
主分类号 |
A61F13/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|