发明名称 |
COMBINATION OF AN AROMATASE INHIBITOR WITH A BISPHOSPHONATE |
摘要 |
The present invention provides a combination for the treatment of a disease or condition which responds to aromatase inhibition, in particular a proliferative disease, especially a malignant disease such as breast cancer or similar soft tissue endocrine-sensitive cancer, most preferably breast cancer, comprising an aromatase inhibitor and a bisphosphonate for simultaneous, concurrent, separate or sequential use in the prevention of bone loss which is caused by the treatment with an aromatase inhibitor. Also provided is a method of treating a patient suffering from a disease or condition which responds to aromatase inhibition comprising administering to the patient an effective amount of a bisphosphonate and an effective amount of an aromatase inhibitor.
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申请公布号 |
CA2494345(C) |
申请公布日期 |
2011.11.29 |
申请号 |
CA20032494345 |
申请日期 |
2003.07.29 |
申请人 |
NOVARTIS AG |
发明人 |
BHATNAGAR, AJAY S.;EVANS, DEAN BRENT;GASSER, JURG ANDREAS;GREEN, JONATHAN |
分类号 |
A61K31/675;C07D249/08;A61K31/35;A61K31/4196;A61K31/663;A61K45/00;A61K45/06;A61P19/08;A61P35/00;A61P43/00 |
主分类号 |
A61K31/675 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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