| 摘要 |
The invention provides a drug dosage form prepared by compression techniques comprising: a thyroid drug treated with a first pharmaceutically acceptable oil to substantially waterproof the thyroid drug; and a pharmaceutically acceptable excipient admixed with a second pharmaceutically acceptable oil to substantially waterproof the pharmaceutically acceptable excipient, wherein the first pharmaceutically acceptable oil is different from the second pharmaceutically acceptable oil; the drug dosage form prepared by: (a) dispersing the thyroid drug in the first pharmaceutically acceptable oil; (b) admixing the excipient and the second pharmaceutically acceptable oil; and (c) compacting the thyroid drug and the excipient into dosage forms using compression pressures of up to 5,000 psi/g. The dosage form may be used for treating a patient in need of thyroid replacement therapy.
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