发明名称 |
Methods for enhancing the therapeutic efficacy of topoisomerase inhibitors |
摘要 |
Disclosed are methods and compositions useful in identifying an E3 ubiquitin ligase inhibitor and modulating cell growth, comprising contacting a cell with an effective amount of an inhibitor of an E3 ubiquitin ligase, and contacting the cell with an effective amount of a topoisomerase inhibitor, wherein the treatment with the E3 ubiquitin ligase inhibitor and topoisomerase inhibitor modulates cell growth in comparison to a cell treated with the topoisomerase inhibitor alone. The present invention further provides methods for identifying and making an E3 ubiquitin ligase inhibitor. |
申请公布号 |
US8067473(B2) |
申请公布日期 |
2011.11.29 |
申请号 |
US20080009310 |
申请日期 |
2008.01.16 |
申请人 |
EREZ OMRI;ALCHANATI IRIS;NAKACHE PHILIPPE;TEVA PHARMACEUTICAL INDUSTRIES, LTD. |
发明人 |
EREZ OMRI;ALCHANATI IRIS;NAKACHE PHILIPPE |
分类号 |
A01N43/40;A01N29/04;A01N43/42;A61K31/25;A61K31/44 |
主分类号 |
A01N43/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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