| 摘要 |
<p>Disclosed are antibody fusion proteins with a modified FcRn binding site and nucleic acid molecules encoding them. The antibody fusion protein include two polypeptide chains, wherein the first polypeptide chain includes a biologically, preferably therapeutically active molecule linked to at least a portion of an immunoglobulin constant region. The second polypeptide chain includes at least a portion of an immunoglobulin constant region. One of the polypeptide chains includes a mutation in the constant region that results in reduction or loss of FcRn binding but does not cause substantial reduction of serum half-life of said antibody fusion protein. In a preferred embodiment the invention relates to respectively constructed Fc-IFNβmolecules. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins for treating diseases and conditions alleviated by the administration of the fusion proteins.</p> |
