| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to C-phenyl-1-thioglucitols of formula (I), [formula I] , where X is a hydrogen atom or a C1-6alkyl group, Y is a C1-6alkylene group or -O-(CH2)n- (where n equals a integer from 1 to 5), and Z is -CONHRA or -NHCONHRB (provided that when Z is -NHCONHRB, n is not equal to 1), where RA is a C1-6alkyl group substituted with 1-3 substitutes selected from a group consisting of a hydroxyl group and -CONH2, and RB denotes a hydrogen atom or a C1-6alkyl group substituted with 1-3 substitutes selected from a group consisting of a hydroxyl group and -CONH2, and pharmaceutically acceptable salts thereof or hydrates thereof. The invention also relates to a sodium-dependent glucose transporter 1 (SGLT1) activity inhibitor, a sodium-dependent glucose transporter 1 (SGLT1) and sodium-dependent glucose transporter 2 (SGLT2) activity inhibitor, as well as a prophylactic or therapeutic agent against diabetes. ^ EFFECT: obtaining novel biologically active compounds which are sodium-dependent glucose transporter 1 and sodium-dependent glucose transporter 2 activity inhibitors. ^ 5 cl, 11 ex, 4 tbl |
