| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of producing a radioactive fluorine-labelled organic compound of formula (3). The method involves a step for splitting an ester of formula (1), where R1 is a straight or branched C1-C10 alkyl and R2 is a protecting group selected from straight or branched C2-C7 alkyloxycarbonyl groups, passed through and held in a reverse phase column containing filler with a structure in which C2-C18 alkyl groups are attached to a substrate by silicon. In order to split said ester, alkali solution is fed into the column, after which alkaline solution is discharged from the column to obtain a compound of formula (2), where X is sodium or potassium and R2 is a protecting group selected from straight or branched C2-C7 alkyloxycarbonyl groups. At the next step, the protecting group R2 of the compound of formula (2), obtained at the ester splitting step, is removed to obtain a compound of formula (3). ^ EFFECT: method enables to reduce the amount of nonradioactive impurities and obtain a compound of formula (3) with good output. ^ 2 cl, 3 dwg, 5 tbl, 2 ex |
