| 摘要 |
A pharmaceutically acceptable liquid otic composition for administration to a non-human animal comprising about 0.1 to about 10% by weight buprenorphine, a pharmaceutically acceptable carrier system comprising about 10 to about 80% by weight of a solvent consisting of a water phase and organic phase, and at least one penetration enhancing agent, wherein the at least one penetration enhancing agent consists of propylene glycol monolaurate, wherein the organic phase of the solvent comprises at least one organic solvent selected from the group comprising 2- pyrrolidone, glyceryl formal, dimethylformamide, N-methyl-pyrrolidone, propylene glycol, polyethylene glycol, diethylisosorbide, ethanol, isopropanol, 1,2-propanediol, glycerin, triethyl citrate, benzyl alcohol and dimethylisosorbide, wherein the composition has a pH within the range of about 3.5 to about 6, and wherein said composition is in a single dose form.
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