ANTITUMORAL COMPOUNDS

摘要

Disclosed is a compound of general formula I wherein Y is selected from -CHRay-, -CHRay-CHRby-, -CRay=CRby-, -C=C-, -CHRay-CHRby-CHRcy-, -CHRay-CRby=CRcy-, and -CHRay-C=C-; each Ray, Rby, and Rcy is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; each R1, R2, R3, R4, and R5 is independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; R6 is selected from NR8R9, and OR10; W is selected from O and NR7; R7 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl, or R7 and R8 together with the corresponding N atom and C atom to which they are attached may form a substituted or unsubstituted heterocyclic group; R8 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkenynyl; R10 is selected from hydrogen, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; each dotted line represents an optional additional bond with the proviso that one or more additional bonds are present, but when a triple bond exists between the C atoms to which R1 and R2 are attached, R1 and R2 are absent, and when a triple bond exists between the C atoms to which R3 and R4 are attached, R3 and R4 are absent; R9 is selected from hydrogen, CORa, COORa, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, and substituted or unsubstituted C4-C12 alkenynyl; each R11, R12, R13, R14, and R15 are independently selected from hydrogen, halogen, ORa, CORa, COORa, OCORa, OCOORa, OCONRaRb, CONRaRb, OS(O)Ra, OSO2Ra, OP(O)(Ra)ORb, OSiRaRbRc, NRaRb, NRaCORb, NRaCONRaRb, NRaS(O)Rb, NRaSO2Rb, NRaC(=NRa)NRaRb, SRa, S(O)Ra, SO2Ra, S(O)NRaRb, SO2NRaRb, S(O)ORa, SO2ORa, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, and substituted or unsubstituted C2-C12 alkynyl; and each Ra, Rb, and Rc are independently selected from hydrogen, substituted or unsubstituted C1-C12 alkyl, substituted or unsubstituted C2-C12 alkenyl, substituted or unsubstituted C2-C12 alkynyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclic group; or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof.