| 摘要 |
<p>Disclosed is a process for preparing N-propargyl 1-indanamine ((1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine also termed as Rasagiline) or its enantiomer, which comprises: (a) reacting racemic 1-aminoindan or its enantiomer with an allyhalide in presence of a base to give N-allyl-1-aminoindan or its enantiomer; (b) halogenating the N-allyl-1-aminoindan or its enantiomer with a halogenating agent in a suitable organic solvent to give N-(2,3 dihalo propyl)-1-aminoindan or its enantiomer; and (c) treating the N-(2,3-dihalo propyl)-1-aminoindan or its enantiomer with a suitable base to give N-propargyl 1-indanamine or its enantiomer. Also disclosed in the intermediate N-(2,3-dibromo propyl)-1-aminoindan.</p> |
