发明名称 |
METHODS OF EXPRESSING A POLYPEPTIDE IN THE BRAIN AND NUCLEIC ACID CONSTRUCTS CAPABLE OF SAME |
摘要 |
A nucleic acid construct and construct system are disclosed. The nucleic acid construct and system comprise a regulatory sequence which regulates inducible expression of a polypeptide of interest, the regulatory sequence comprising a choroid plexus specific promoter, with the proviso that the choroid plexus specific promoter is not a transthyretin promoter. Pharmaceutical compositions comprising same and uses thereof are also disclosed.
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申请公布号 |
US2011288159(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US20090934689 |
申请日期 |
2009.03.25 |
申请人 |
CHEN ALON;YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE |
发明人 |
CHEN ALON |
分类号 |
A61K31/7088;A61P15/08;A61P25/00;A61P25/06;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P31/04;A61P31/10;A61P35/00;C12N15/85 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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