发明名称 |
CRYSTALS AND STRUCTURE OF A HUMAN IgG Fc VARIANT WITH ENHANCED FcRn BINDING |
摘要 |
Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
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申请公布号 |
US2011288276(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US200913133845 |
申请日期 |
2009.12.10 |
申请人 |
OGANESYAN VAHEH;DALL'ACQUA WILLIAM F.;WU HERREN |
发明人 |
OGANESYAN VAHEH;DALL'ACQUA WILLIAM F.;WU HERREN |
分类号 |
C07K16/00;C07K1/02;G06F17/50;G06G7/60 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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地址 |
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