Polyethyleneglycol-modified lipid compounds and uses thereof

摘要

Polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates are disclosed which have increased stability over commonly used PEG-lipids conjuguates. Liposomal compositions, stabilized plasmid-lipid particles (SPLP) and stabilized nucleic acid-lipid particles (SNALP) comprising said PEG-DAA conjuguates, for delivery of a bioactive agent to a cell or patient are described.