SYNTHESIS OF ACYLOXYALKYL CARBAMATE PRODRUG AND INTERMEDIATE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide a novel method for synthesis of 1-(acyloxy)-alkyl carbamates.

SOLUTION: The method for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates are also described.

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