发明名称 |
URINARY BIOMARKERS FOR SENSITIVE AND SPECIFIC DETECTION OF ACUTE KIDNEY INJURY IN HUMANS |
摘要 |
The present invention is directed to acute kidney injury biomarkers, and methods and kits comprising the use of agents directed against acute kidney injury biomarkers for facilitating and enhancing the diagnosis of AKI. The present invention is based on the discovery that specific biomarkers are present in urine at higher concentrations in subjects with acute kidney injury (AKI) as compared with subjects that have no symptoms of AKI. The invention is directed to methods for diagnosis of AKI by determining and monitoring the levels of at least one biomarker protein in a biological sample, such as urine. Further, the invention is directed to methods for facilitating the distinction of kidney infection from bladder infection in a subject. |
申请公布号 |
US2011287964(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US200913129600 |
申请日期 |
2009.11.17 |
申请人 |
BONVENTRE JOSEPH V.;VAIDYA VISHAL S.;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
BONVENTRE JOSEPH V.;VAIDYA VISHAL S. |
分类号 |
C40B30/04;C12Q1/34;G01N33/566;G01N33/573 |
主分类号 |
C40B30/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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