发明名称 |
Modulation of inducible nitric oxide (iNOS) binding to SPRY domain-containing SOCS-box peptides (SSB) |
摘要 |
The present invention relates to methods of modulating the level of inducible nitric oxide synthase (iNOS) in a cell which comprises administering to the cell a compound which modulates binding of SPRY domain-containing SOCS box protein (SSB) to iNOS, and/or a compound which modulates SSB activity in the cell. Further provided are methods of treating or preventing disease in a subject by modulating the level of iNOS in a cell, as well as compounds which modulate binding of SSB to iNOS and compounds which modulate SSB activity. |
申请公布号 |
AU2010244972(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
AU20100244972 |
申请日期 |
2010.05.06 |
申请人 |
THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH |
发明人 |
KOLESNIK, TATIANA;KUANG, ZHIHE;LEWIS, ROWENA SUE;NICHOLSON, SANDRA ELAINE;NORTON, RAY |
分类号 |
C07K7/08;A61K38/10;A61K38/43;A61K39/395;A61K48/00;A61P31/00;A61P33/00;C07K16/18;C07K16/40;C12N9/02;G01N33/50 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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