Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.
申请公布号
CA2800173(A1)
申请公布日期
2011.11.24
申请号
CA20112800173
申请日期
2011.05.20
申请人
MERRIMACK PHARMACEUTICALS, INC.
发明人
NIELSEN, ULRIK;WICKHAM, THOMAS;SCHOEBERL, BIRGIT;HARMS, BRIAN;LINGGI, BRYAN;ONSUM, MATTHEW;DELABARRE, BYRON;LIPPOW, SHAUN M.