发明名称 |
ANTI-P-SELECTIN ANTIBODIES AND METHODS OF THEIR USE AND IDENTIFICATION |
摘要 |
Antibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of preformed P-selectin/PSGL-1 complexes. The disclosure identifies a heretofore unrecognized, near N-terminal, antibody binding domain (a conformational epitope) of P-selectin to which the function-blocking antibodies (which may be chimeric, human or humanized antibodies for example) bind. Antibodies are disclosed which bind to the conformational epitope of P-selectin and which have a dual function in blocking binding of PSGL-1 to P-selectin, and in causing dissociation of preformed P-selectin/PSGL-1 complexes. Such single and dual function anti-P-selectin antibodies and binding fragments thereof may be used in the treatment of a variety of inflammatory and thrombotic disorders and conditions. Screening methods for identifying such antibodies are also disclosed. |
申请公布号 |
US2011287017(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US201113204508 |
申请日期 |
2011.08.05 |
申请人 |
ROLLINS SCOTT;ALVAREZ RICHARD;ROTHER RUSSELL;MCEVER RODGER P.;KAWAR ZIAD S. |
发明人 |
ROLLINS SCOTT;ALVAREZ RICHARD;ROTHER RUSSELL;MCEVER RODGER P.;KAWAR ZIAD S. |
分类号 |
A61K39/395;A61P11/06;A61P17/06;A61P29/00;A61P37/06 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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