发明名称 |
SYSTEMS AND METHODS FOR IDENTIFYING DRUG TARGETS USING BIOLOGICAL NETWORKS |
摘要 |
Certain embodiments of the invention may include systems and methods for identifying drug targets using biological networks. According to an example embodiment of the invention, a method, is provided for predicting the effects of drug targets on treating a disease. The method can include constructing a structure of a. Bayesian network based at least in part on knowledge of drug inhibiting effects on a disease; associating a set of parameters with the constructed Bayesian network; determining values of a joint probability distribution of the Bayesian network via an automatic procedure; deriving a mean Bayesian network with one or more averaged parameters based at least in part on the joint probability values; and calculating a quantitative prediction based at least in part on the mean Bayesian network. |
申请公布号 |
WO2011146619(A2) |
申请公布日期 |
2011.11.24 |
申请号 |
WO2011US37001 |
申请日期 |
2011.05.18 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;WANG, WEI;CHANG, RUI |
发明人 |
WANG, WEI;CHANG, RUI |
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