发明名称 |
TRIGGERED COVALENT PROBES FOR IMAGING AND SILENCING GENETIC EXPRESSION |
摘要 |
The present invention relates to the use of cross-linking probes to covalently bind probes to nucleic acid targets. In some embodiments, the probe comprises an initiator region that is able to bind to a first portion of a target nucleic acid, a probe region linked too the initiator region that is able to bind to a second region of the target nucleic acid and that comprises one or more cross-linkers, and a blocking region hybridized to the probe region. |
申请公布号 |
US2011288148(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
US201113016811 |
申请日期 |
2011.01.28 |
申请人 |
PIERCE NILES A.;VIEREGG JEFF ROBERT |
发明人 |
PIERCE NILES A.;VIEREGG JEFF ROBERT |
分类号 |
A61K31/7088;A61P31/04;A61P31/12;C07H1/00;C07H21/00 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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