COMPOSITION FOR SCREENING AND A SCREENING METHOD FOR SUBSTANCES ACTIVE IN TREATING HEPATITIS B

摘要

The present invention is for screening for substances that selectively inhibit binding between DDX3 proteins and HBV polymerase as distinct from the molecules of the virus itself, and it can be expected that not only will there be only a very remote possibility of mutant viruses occurring that have resistance to avoid the same but also that the cytotoxicity with respect to host cells will be extremely low since the invention entails a target that is formed specifically only in infected cells. In particular, there is the advantage that the invention is outstanding in terms of cytotoxicity and the low occurrence of resistant mutations in chronic hepatitis B requiring long-term treatment of 1 year or more.