| 摘要 |
<p>Disclosed are inhibitors of human 12-lipoxygenase of Formula (I) or (II), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating or preventing a 12-lipoxygenase mediated disease or disorder, e.g., diabetes. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal.</p> |
| 申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;EASTERN VIRGINIA MEDICAL SCHOOL;THOMAS JEFFERSON UNIVERSITY;MALONEY, DAVID J.;HOLMAN, THEODORE;JADHAV, AJIT;SIMEONOV, ANTON;BANTUKALLU, GANESHA RAI;NADLER, JERRY L.;HOLINSTAT, MICHAEL |
发明人 |
MALONEY, DAVID J.;HOLMAN, THEODORE;JADHAV, AJIT;SIMEONOV, ANTON;BANTUKALLU, GANESHA RAI;NADLER, JERRY L.;HOLINSTAT, MICHAEL |
