| 摘要 |
Fusion constructs with i) a domain that is specific for binding, on the surface of a cell, a lipid that is characteristic of the cell, and ii) a domain or agent that possesses an activity of interest that impacts the cell, are provided. Binding of the fusion construct to the characteristic lipid results in attachment of the construct to the cell and 1) expression of the activity of interest at the cell surface or, 2) entry of the construct into the cell, so that the activity of interest is expressed inside the cell. The cell may be a pathogen, cancer cell or other pathological cell displaying a characteristic lipid, and the domain or agent may be toxic or inhibitory to the cell. Alternatively, the cell may be non- pathogenic and the activity of interest may elicit a desired response from the cell, e.g. cell division, up regulation of a gene sequence, etc. |
