发明名称 |
Method for making heteromultimeric molecules |
摘要 |
The present invention provides methods for making heteromultimeric molecules, such as bispecif&idigr;c antibodies, and compositions comprising said molecules. The method includes introducing mutations in amino acids that are in contact at the interface of two polypeptides, such that the electrostatic interaction between the ion pairs is altered. |
申请公布号 |
AU2010245011(A1) |
申请公布日期 |
2011.11.24 |
申请号 |
AU20100245011 |
申请日期 |
2010.04.27 |
申请人 |
ONCOMED PHARMACEUTICALS, INC. |
发明人 |
GURNEY, AUSTIN L.;SATO, AARON KEN |
分类号 |
A61K39/395;C12P21/06;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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