5-pyridin-3-yl-1,3-dihydro-indol-2-on derivatives and their use as modulators of aldosterone synthase and/or CYP11B1

摘要

The present invention provides a compound a formula (I); or a pharmaceutically acceptable salt thereof, wherein: X is CH, O, S or-NR; each R are independently Calkyl or Ccycloalkyl; each of R and R are independently hydrogen, halogen, cyano, Calkyl, hydroxy-Calkyl, -OR, Ccycloalkyl, halo-Calkyl or -CH-NR-SO-R; R and R are independently hydrogen, halogen or cyano; R is hydrogen, Calkyl, halogen, cyano, hydroxy, hydroxy-Calkyl, hydroxy-C cycloalkylalkyl, Calkoxy-Calkyl, -OR, Caryl, heteroaryl, heterocyclyl, C cycloalkyl, halo- Calkyl, -NRR, -CHNR-C(O)NRR, -CH-NR-SO-R, -C(O)- R, -SOR, -C(O)-NRR -SO-NRR, -NRC(O)-R -CHCN, or -NR-SO-R. Compounds of the invention may be useful in the treatment of a disorder or disease mediated by aldosterone synthase and/or 11-beta hydroxylase (CYP1 181).